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This Concept Map, created with IHMC CmapTools, has information related to: Immuno map, Macrophages Secrete proinflammotory cytokines such as: IL-1-beta IL-6 TNF-alpha CXCL8 IL-12, IFN-β Activates and causes proliferation of NK Cells, Complement Pathways: MBL: activates the lectin pathway CRP: activates the classical complement pathway Pathogen: Activates the Alternative complement Pathway produces C5 convertatse (C3b2Bb) which cleaves C5 forming C5b leading to the formation of Membrane Attack complexes (MAC): C5b + C6+ C7 + C8 + C9 C5bC6C7C8 + many C9, TLR4 Which activates TRIF:TRAM, IgG (most common, transplacental, can opsonizie pathogens) Binds to and coats a pathogen thus activating (a process called Antibody-dependant cell-mediated cytotoxicity; ADCC. Specifically IgG1 and IgG3 binding to FcγRIII receptor on NK cells) NK Cells, Pathogen Recongnized and captured by Immature DCs, IL-1-beta IL-6 TNF-alpha CXCL8 IL-12 Activating (IL-12, TNF-α) NK Cells, Th1 Secretes Cytokines: IL-2 (induces T cell proliferation by binding to IL-2R [CD25] that mature T cells express) IFN-γ (Stimulates isotype switching to IgG3 or IgG2a), Th2 inhibits by the production of IL-4,IL-10,IL-13 Th1, Th1 Secretes IL-2 to activate CD8 T + cells, Mature DCs (produce CCR7 and increase MHC II expression to present Antigens) Secrete IL-12 and TNF-α, activating NK Cells, CD4+ T cell clonal expansion Stimulate the differentiation into (Induced by IL-12) Th1, Th2 Recruit (using IL-5) Mast Cells, CD4+ T cells Undergo CD4+ T cell clonal expansion, IgA (Dimer, hooked by J-chain. Important on mucoid surfaces/secretions. Eyes, GI,GU) Provide Immunity to the infant for atleast 3 mo after birth, Complement Pathway: Classical Complement Pathway produces C5 convertatse (C3b2Bb) which cleaves C5 forming C5b leading to the formation of Membrane Attack complexes (MAC): C5b + C6+ C7 + C8 + C9 C5bC6C7C8 + many C9, B-1 Cells (in fetus..aka CD5 B cells) are primarily cells of the innate immunity, Eosinophils Secrete histamine (vasodialation) and heparin (anti-coag),IL-3,IL-5,GM-CSF that target Parasitic Infection Type I hypersensitivity, Local Infection/ Disturbance Recognized by (through MHC and also lipids) Gamma:delta T cells (abundant in epithelial cells rep 5% of T cells), IRF3 Causing A virally infected cell